Paper on influence of serosorting on HIV pre-exposure prophylaxis published

The paper “Mathematical modelling of the influence of serosorting on the population-level HIV transmission impact of pre-exposure prophylaxis“, led by Linwei Wang and team, was recently accepted and published online in AIDS.

Brief summary:
Patterns of “who has sex with whom”, such as serosorting, influence how HIV may spread and persist, and thus how interventions may fare among a population. Serosorting is a common practice among men who have sex with men (MSM) to reduce HIV risk via preferential partnership formation between individuals of the same perceived HIV status. We developed a mathematical model of HIV transmission to evaluate the influence of serosorting on the population-level impact of HIV pre-exposure prophylaxis (PrEP) in reducing HIV incidence among MSM in Canada. We found that ignoring serosorting in the model could underestimate the population-level HIV-incidence reductions due to PrEP. PrEP-mediated changes in serosorting (men on PrEP stopped vs. continued serosorting) could lead to programmatically-important reductions in PrEP-impact under low PrEP-effectiveness. Our findings suggest the need to monitor sexual mixing patterns to inform PrEP implementation and evaluation.

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